منابع مشابه
NKT Cell Responses to B Cell Lymphoma
Natural killer T (NKT) cells are a unique subset of CD1d-restricted T lymphocytes that express characteristics of both T cells and natural killer cells. NKT cells mediate tumor immune-surveillance; however, NKT cells are numerically reduced and functionally impaired in lymphoma patients. Many hematologic malignancies express CD1d molecules and co-stimulatory proteins needed to induce anti-tumor...
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Immunomodulators are effective in controlling hematologic malignancy by initiating or reactivating host antitumor immunity to otherwise poorly immunogenic and immune suppressive cancers. We aimed to boost antitumor immunity in B-cell lymphoma by developing a tumor cell vaccine incorporating α-galactosylceramide (α-GalCer) that targets the immune adjuvant properties of NKT cells. In the Eμ-myc t...
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1 Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America, 2 Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, United States of America, 3 Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut, United States of America, 4 Yale Cancer Center, New Haven, Connecticut, United States ...
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The material in this supplement was not able to be included in the paper. It is meant for those who would like to know more details of the behavior of the two methods for fitting the diffusion model to data. It concerns some additional discussion of efficiency and accuracy of parameter estimates, a discussion of overfitting, presentation of parameter tradeoffs in the model (showing a very stron...
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In this rejoinder, we address two of Ratcliff's main concerns with respect to the EZ-diffusion model (Ratcliff, 2008). First, we introduce "robust-EZ," a mixture model approach to achieve robustness against the presence of response contaminants that might otherwise distort parameter estimates. Second, we discuss an extension of the EZ model that allows the estimation of starting point as an add...
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ژورنال
عنوان ژورنال: Blood
سال: 2019
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.2019003023